Integumen License Ageement

Integumen License Ageement

Joining forces with Integumen for sales of Omega 3 and bioplastics

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus Glover, Chief Executive Officer and Chief of Operations of Cellulac respectively, will join the Board of Integumen and take up management in parallel roles to those held in Cellulac.

Gerard Brandon (Chairman & CEO of Cellulac) commented:

“Cellulac has novel technology and IP with commercial traction. The marriage of this technology and Integumen’s consumer presence online and in other retailers will create a supply source to customer supply chain of natural oils and biodegradable plastic ingredients to a number of sectors.

The environmental impact of single-use plastics is well documented and increasing awareness of the harm it is causing to our planet has driven governments, companies, and individuals to abandon the use of these materials and seek alternative solutions. We believe we are strongly placed to provide an effective and more eco-friendly solution.”

Tony Richardson (Chairman of Integumen) commented:

“The Board acknowledges the challenges Integumen has faced in generating returns for shareholders. We have been working hard to identify the best route forward and we believe acquiring a stake in Cellulac presents a number of opportunities to accelerate revenue generation. The economic and environmental drivers of biodegradable plastics are compelling driven by the global attitudinal shift against single-use plastics, creating strong potential demand for Cellulac’s products. We believe the actions we are taking will position us well for the future.

The wealth of experience and expertise that Gerard Brandon and Camillus Glover bring to their respective new roles of Chief Executive Officer and Chief Operations Officer at Integumen, I believe, will see accelerated growth across the business.”

Full details of the announcement can be seen on the London Stock Exchange website here

Integumen License Ageement

Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

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Low Energy Microalgae to Biofuel at Commercial Scale

Low Energy Microalgae to Biofuel at Commercial Scale

Low Energy Biomass to Bio-fuel at Commercial Scale

Food and Fuel for the 21st Century

 

Microalgae have come to the attention of the industrial and academic community over recent years because of their ability to harvest the energy of the sun and provide valuable molecules that offer great potential to provide fuel for the coming century and relieve the need and destructive outcomes that are associated with traditional fossil fuels.

 

Solvent-free wet extraction of fuels and sugars

 

For commercial microalgal biofuels to become a reality, the high production cost of oil extraction must be dealt with. A large contributor to the production cost base is the solvent-based process for cell destruction and oil extraction from the algae, which is both expensive and environmentally damaging.

 

4 year pilot to commercial scale success

 

Cellulac recently concluded a 4-year pilot scale to commercial scale project using the SoniqueFlo Sono-Enzymolysis Cell Disruption process with specific objectives to:

 

  1. Demonstrate the technical feasibility of cell wall breakage of Nannochloropsis and Schizochytrium;
  2. Validate a lower cost for enzyme-solvent free extraction compared to the solvent-based process;
  3. Verify environmental benefits of the enzymatic-solvent free process;
  4. Obtain required regulatory approvals for food-grade algal oil extracted using enzymes; and
  5. Leverage project results to commercialize enzymatically extracted algal oil and achieve sales of lysis technology to producers of algal oils.

SoniqueFlo treatment significantly damaged or destroyed cells.

 

Schizochytrium samples post-treated with enzyme:

  • Confirmed a greater than 10 fold reduction in the enzyme dose required for lysis.
  • 87-94 % of available lipid was separated from hydrolysis reaction using a disk stack centrifuge
  • Shortening of hydrolysis time to just 2 hours was also possible.

The success of this trial indicates strongly that SoniqueFlo technology undoubtedly has a role to play in improving the economics of commercial-scale production using an enzyme-based solvent free wet extraction process of algal oils.

 

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Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

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Cellulac Formally Requests Metabolix Shareholders to Consider Merger Proposal

Cellulac Formally Requests Metabolix Shareholders to Consider Merger Proposal

Cellulac Formally Requests Metabolix Shareholders to Consider Merger

Cellulac merger proposal to Metabolix worth $40m in assets and offtake agreement of $38m rejected in favor of closing biopolymer business and spending $35m over 7 years on crop science project with no revenue.

 

DEAR METABOLIX SHAREHOLDERS

 

me

London, UK. 25th July, 2016: Cellulac plc (@cellulac), is an industrial biochemicals investment technology company. Cellulac have been interested in Metabolix Inc., ($MBLX) for some time and after their announcement, in May 2016, of a strategic review, Cellulac made a formal proposal via the CEO to merge both companies. The proposal meant Cellulac would contribute industrial scale production assets with biochemical and biopolymer capacity, independently valued at up to $40m. In addition, terms for a manufacturers licensing agreement of the combined Metabolix and Cellulac biopolymer assets with access to debt and equity funding from Cellulac assets and shareholders for a commercially focused growth strategy of the enlarged entity.

 

The Board of Directors of Metabolix decided the $40m merger offer was not important enough to inform shareholders

 

A merger with Cellulac, based on the biopolymer intellectual property and associated institutional knowledge, would reduce Metabolix development overhead to a more manageable level where manufacturing license fees and future royalties would transform Metabolix, for the first time in 24 years, into a profitable part of an enlarged bio-based company. Synergies would contribute shared management and development costs across a larger corporate group, multiple revenue streams comprising of production equipment installations, recurring revenue from biochemical production, manufacturing product licensing agreements, process licensing with biopolymer offtake agreements worth $38m already in place.

 

Right up to July 2016, Metabolix continued to burn $2m a month. This was no surprise considering the content of the presentation at the Roth Investor Conference on the 15th March 2016 and reiterated in the year-end report later that month.

 

March 29th Metabolix conference call to investors the CEO stated:

 

“Looking ahead the company is turning its attention to the next step, moving from commercial pilot-scale operations to a commercial-scale specialties business”.

 

Yet within 7 weeks Metabolix had sold the exclusive global rights and future royalties on PHA use in medical devices for the price of less than one month’s burn rate.

 

Astonishingly, after wasting 2 months and what appears to be a further $4m in costs, the Metabolix Board declined the Cellulac merger offer.

 

The Board of Metabolix has been responsible for:

 

  1. The supervision, over 24 years, of $326m invested by shareholders in biopolymer research and development
  2. Appointing the current CEO in January 2014
  3. Raising and overseeing the current CEO spend $40m on the biopolymer business
  4. Presiding over an 89% drop in shareholder value in the last 30 months; and
  5. A 99% drop from all-time high
The same Board has now decided to:

 

  1. Write off the entire biopolymer business
  2. Dismiss 48 people relating to the biopolymer business
  3. Pursue a path of further shareholder value destruction in questionable scientific research for the next 7 years as a public company.
In a written note a former Metabolix Senior Scientist said:

 

In the case of PHA producing plants the PHA content in one leaf could not represent the low overall content of PHA in the biomass. Many public presentations were not telling the exact picture, but rather the ‘nice numbers’. As a scientist I always challenged this phenomena. The plant project today is on the table for rapid growing biomass. But knowing the rate limiting factors in growing plants it will not solve the world problems…

Cellulac Core Terms

 

  1. Cellulac merge on a 50/50% share for share basis with Metabolix
  2. The immediate cessation of the current business model of Metabolix avoiding further unnecessary expenditure
  3. The restructuring/divestment of the high R&D overhead and associated costs of Metabolix
  4. The business model focused on the commercial activities at the core of Cellulac technology
  5. Metabolix is renamed Cellulac to indicate a change of business model away from the R&D to a commercially focused Company
Questions for the Board

 

 

I have three questions for the Metabolix Board of directors:

 

  1. Why did you decline a merger proposal, without informing shareholders, valuing Metabolix in excess of $35m offering industrial scale biochemical and future biopolymer production capacity, access to asset backed debt and equity funding for commercial growth delivering multiple revenue streams from a combined technology platform that would make Metabolix a profitable contributor of the enlarged corporate entity?
  2. Was there a Board decision in May 2016 to close the biopolymer business when the Board signed off on the sale of patents for the exclusive global use of PHA in the high margin medical device sector for $2m, and if so, why was management allowed to burn through another $4m until the end of July 2016?
  3. Why are you willing to subject shareholders to 7 more years of equity value destruction by dilution, at $5m costs a year, with no foreseeable revenues, in an early stage research and development project, other than for survival with access to government grants?
In Closing

 

 

In my opinion, by declining the offer from Cellulac, current management and Metabolix Board demonstrate a complete lack of business acumen or commercial vision. Displaying utter contempt for shareholder value they are adopting a strategy that requires investment of $35m over the next 7 years leading to further destruction in equity value with no visibility of revenue, other than government grants.

 

It is incumbent upon the Board members, but especially Independent Directors, majority and minority shareholders to immediately review the reasons for this illogical decision and become vocal about Cellulacs’ offer that adds $40m in biochemical and biopolymer assets for commercial scale production and manufacturer licensing and offtake agreements. This is likely to be the last opportunity to transform Metabolix, a 24 year loss making company, into part of a high growth enlarged group with multiple revenue streams for biochemicals and biopolymers, which would be cash generative this year.

Gerard Brandon
Chief Executive

 

Address

Registered Office

Finsgate, 5-7 Cranwood Street, London EC1V 9LH

Call us from UK +44 (122) 392 6660

Call us from US +1 (310) 421 2910

NOTES TO EDITORS:

 

Cellulac is an industrial biochemicals investment technology company that collaborates with, and acquires, companies to exploit the combined production, intellectual property assets and institutional knowledge. We out-license non-core technology and expertise in exclusive and non-exclusive agreements, while at the same time, developing and extracting maximum value from the remaining core production and intellectual property assets that we acquire.

 

We seek to identify enzyme, bacteria, chemical process, fluid dynamic, electrical and software engineering efficiency opportunities within the bio-industrial technology sector that offer management synergies and hybrid integration and value added benefits to our existing technology platform. Such various technology combinations deliver valuable additions to production processes, improving margins and reducing costs in the bio-fuel and bio-chemical sector.

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Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

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Cellulac Acquires Aer Sustainable Energy (Aer-Bio)

Cellulac Acquires Aer Sustainable Energy (Aer-Bio)

Cellulac Acquired Aer-Bio

10 fold saving in enzymes, 4 fold increase in algae oils within 2 hours reducing the process costs of Omega-3, animal feed and biofuels

 

Dublin, Ireland, 18th May 2015: Cellulac, the industrial biochemicals company, today announces the acquisition of Aer Sustainable Energy Limited, also known as Aer-Bio, effective 18th May 2015. The acquisition adds to the production capabilities in the bioplastic ingredients and biochemical sectors by adding foods, cosmetics, nutraceutical products and aviation biofuel to the core institutional knowledge of the Cellulac technology platform.

 

Aer-Bio+SoniqueFlo-Chart

 

The combination of the Cellulac SoniqueFlo technology – an environmentally-benign, low cost production of chemicals from bio-based dairy and agriculture feedstocks – and Aer-Bios’ accelerated enzyme-expression protocols, have delivered a revolutionary ‘wet extraction’ process for the extraction of oils, proteins and other value-added products from algae. Using a pilot scale SoniqueFlo rig, with the capability of processing up to 10 tonnes per hour, the results showed a 10 fold reduction in enzyme use and 4 fold increase in lipid/oils extraction from algae over a 2 hour period.

 

Gerard Brandon, CEO of Cellulac, commented;

 

“This is a major breakthrough because of the elimination of biomass drying steps that substantially reduce production costs of oil based products from Algae along with the removal of hazardous solvents for oil recovery. Aer-Bios’ contribution has been invaluable to Cellulac within our SPLASH (biopolymer) and FUEL4ME (biofuel) EU grant supported algae projects as the results show. We have industrial scale capability and are currently only limited by the supply constraints of Algae raw materials to process.”

Dr Alan Hernon Ph.D., CEO of Aer-Bio Limited;

“We are excited to have joined one of Europe’s fastest growing bio-based industry companies and believe that joining the Cellulac group offers our combined technologies greater opportunity to reach a wider global bio-economy audience.”

Background on Aer-Bio

 

AER BIO, Aer Sustainable Energy Limited, trading as Aer-Bio, is an Irish industrial biotechnology company. The company has developed an enzyme-based process delivering a revolutionary ‘wet’ extraction method for manufacturing bio-based oils, proteins and other valuable products from Algae. Products that can be extracted and refined using these methods include functional food products such as Omega-3 oils, personal care ingredients, industrial oils and aviation biofuels. Shareholders include Irelandia Investments, Tedcastle Oil, AIB-Seed Fund and Enterprise Ireland.

 

SoniqueFlo Test Rig – 10 tonnes per hour

 

SoniqueFlo Test Rig

SoniqueFlo Industry Scale Rig – 120 tonnes per hour

 

SoniqueFlo

This SoniqueFlo unit has built in 50% redundancy for continuous processing while one side is being cleaned or maintained.

 

Products Algae End Use Markets
Oils/Lipids
  • Algae oils can be a substitute for vegetable oil feedstocks (e.g. Palm, Soybean)
  • Refined glycerine produced for biodiesel may also be used in the pharmaceutical and consumer product industries (cosmetics, skin, beauty care, Omega-3)
  • Specialty oils and fatty acids for dietary supplements and other consumer care applications
Carbohydrates
  • Substitution of agricultural sourced feedstocks for conversion of carbohydrates (sugars) to bio-ethanol (e.g., corn, wheat, sugar cane and sugar beets)
  • Production of bio-based polyolefin plastics as biodegradable replacement of fossil fuel feedstocks
Proteins
  • There is a high protein content in algae biomass for the animal food market, replacing agricultural-based protein sources (e.g., soybean meal)
Hydrocarbons
  • Production of renewable fuel for substitution of diesel, ethanol and aviation fuels for commercial, industry and aviation sector
Biomass
  • Feedstock source for biomass power generation as a substitute for fossil fuels
  • Conversion of residual biomass following oil extraction to renewable distillates
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Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

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5 year, €35m Pharmafilter Partnership with Cellulac

5 year, €35m Pharmafilter Partnership with Cellulac

5 Year, €35m Pharmafilter Offtake Agreement for Bioplastic Ingredients

Partnership delivers 2nd generation bioplastics supply chain solution for hospitals

 

Dundalk, Ireland and Amsterdam, The Netherlands, 30th March 2015: Cellulac, the industrial biochemicals company, and Pharmafilter, a provider of integrated waste management infrastructure for dealing with complex waste, are delighted to announce a commercial partnership to deliver the first vertically integrated, supply chain solution for energy and wastewater recovery in hospitals.

 

main-tanks-corner52bda811c4a7f.jpgCellulac’s environmentally-benign, low-cost production bioplastic process uses 2nd generation dairy and agriculture feedstocks. Through this commercial partnership, cellulac will produce up to 90% of the core ingredients for disposable single-use items and personal hygiene products compatible with the Pharmafilter recovery system in hospitals. This partnership is a template for collaboration, development, and implementation of end-to-end solutions for advances in technology for the bio-economy.

 

Gerard Brandon, CEO of Cellulac

The Pharmafilter alliance with Cellulac is a classic definition of the bio-economy. Producing, at volume, our low-cost, thermostable and high strength bioplastics for a technology partner would be a significant development alone. However, it becomes transformative when combined with Pharmafilter’s hospital recovery system which is capable of recapturing energy and cleaning wastewater in a safe and environmentally friendly way. Our partnership creates a low cost, vertically integrated supply chain solution that has a low carbon footprint and is environmentally friendly, positioning both cellulac and Pharmafilter as lynchpins in a circular bio-based economy.

Eduardo Van Den Berg Founder and CEO of

 

Our innovative solution solves waste, wastewater and safety problem for hospitals by removing complex waste, sewage and wastewater streams emanating from hospitals. Central to this solution is the requirement to secure a sustainable low cost and low carbon, high energy, end-of-life solution for single use bioplastics. cellulac’s innovative production and operational cost base opens the door for Pharmafilter to meet those targets and we look forward to rolling out the products over the next few years.

 


About Pharmafilter BV

Pharmafilter

Pharmafilter represents a change that positively enhances the work environment, patient safety, and care. It is an environmentally friendly way of dealing with the complex waste, sewage and wastewater streams emanating from hospitals that would normally be contaminated with high concentrations of pharmaceuticals, such as antibiotics, painkillers, toxic substances, heart medicines and contrast media. Through urine and feces, these substances are discharged to the wastewater system and despite excellent biological treatment in wastewater treatment plants, eventually discharged into surface water.

 

Logistically and historically, waste in hospitals is removed and separated into various categories. This activity requires both significant staffing hours, physical infrastructure and recording of waste types. This process requires the use of sorting rooms, internal, external storage and transporting waste through public corridors and lifts. The core benefits are:

 

  1. The on-site plant produces its own electricity and recovers the water to the quality that can be reused in the hospital. It reduces mixed waste (including hazardous) by 50% of the volume including 90% of organic waste representing another cost benefit.
  2. It is a thoroughly integrated waste management system that delivers significant improvement in the handling, removal, and treatment of waste streams arising in hospitals, at every user interface. These include solid waste in the form of bioplastic bedpans, urinals, kitchen refuse, general waste and health care risk waste.
  3. Pharmafilter system greatly simplifies the methods by which waste is handled and decontaminated and, therefore, reduces overall costs.

Pharmafilter Process

 

Starting inside the hospitals individual shredding units (“Tonto”) are installed in service or utility rooms convenient to areas of waste output.

 

Steps:

 

  1. All waste generated in the department and ward from healthcare risk waste, food, sharps, materials contaminated with blood, soiled, pharmaceuticals, paper, plastics, biodegradable bedpans and urine collection units are shredded in the Tonto unit.
  2. Waste now exits the hospital through waste disposal pipes that are now redirected to the Pharmafilter on-site unit rather than the external sewer.
  3. Here the Pharmafilter unit automatically decontaminates and separates all constituents of this mixed waste stream; sewage, organics and water resulting in outputs free of viruses, pathogens harmful bacteria, pharmaceuticals and other trace contaminants.
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Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

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Lactic Acid from Lactose Whey in World First Continuous Production runs

Lactic Acid from Lactose Whey in World First Continuous Production runs

Lactic Acid from Lactose Whey - Continuous Production Run

 

Cambridge, UK. 19 May 2014: Cellulac, the industrial biochemicals company is delighted to announce the world’s first ever industrial level continuous production of lactic acid from deproteinized lactose whey. Our 10 day production run concluded this week and delivered optically pure D(-) Lactic Acid suitable for conversion to bioplastics.

 

Whey is considered a high volume wastewater obtained as a by-product of the cheese production process following the separation of fat and casein from milk. As it has a high chemical oxygen demand it is considered a major pollution problem for the dairy industry. Cellulac’s cutting edge technology is able to take this by-product and convert it into lactic acid which can be used in the production of bioplastics as well as other industrial chemicals.

 

Gerard Brandon, CEO of Cellulac, commented;

 

We are the first company to achieve continuous production of optically pure lactic acid from deproteinized lactose whey at industrial scale. This is a major breakthrough that we will exploit in our Dundalk plant, Ireland, as we build out our Phase 1 production of up to 20,000 tonnes of high specification ingredients. Our resulting lactic acid can be used for industrial strength and heat resistant bioplastics. The use of such 2nd generation alternative source of sugars, in addition to our continuous runs, leads to significant savings in time, productivity, quality, recoverable additives, and ultimately a lower production cost.

 

“Our innovative solution not only solves a pollution problem for dairy processors, but creates a major value-added product to the agricultural sector in a market deemed to be reliant on commodity prices which are set to come under further pressure from removal of EU Milk Quotas next year.

40% cost saving over first generation Lactic Acid production

 

Cellulac expect a reduction in cost of production of optically pure Lactic Acid in excess of 40% compared to current approaches that rely on sugar and starch (first generation) feedstocks for a number of reasons.

 

Feedstocks Tested Since 2007

 


Feedstcck Tested for Lactic Acid

 

  • The Cellulac bio-production process utilises raw materials that are second generation feedstocks, including lactose whey and lignocellulosic materials (eg straw, spent brewers’ grains, ethanol producers’ distilled dried grains with solubles). These are by products resulting from other commercial or agricultural processes and as such have little intrinsic commercial value, guaranteeing low input costs. By contrast, first generation feedstocks used in alternative bio-production platforms are highly sensitive to commodity price inflationary pressures as a result of their use as basic food crops.
  • The Cellulac process significantly reduces the combined cost of energy and enzymes for the conversion of raw feedstocks to fermentable sugars when compared to alternative pre-treatment systems such as steam explosion. This results from the application of the SoniqueFlo™ cavitation technology in the pre-treatment of such feedstocks and the use of cellulac’s proprietary cocktail of enzymes to furnish high yields of both C5 / C6 fermentable sugars for subsequent downstream conversion to biochemicals.
  • The Cellulac process removes the majority of the energy costs associated with the downstream processing of fermentation broth to Lactic Acid by the innovative use of supersonic energy and CO2 in SoniqueFlo™ to produce ethyl lactate, an industrial organic solvent derived from Lactic Acid. Conventional processing is highly energy intensive and consumes as much as 67% of the overall cost of Lactic Acid production.
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Integumen License Ageement

Today, Cellulac announces that it has signed Heads of Terms to enter into a commercial technology agreement with Integumen (LSE: SKIN). In addition, Integumen has conditionally agreed to acquire 9.35% of the issued shares of Cellulac. Gerard Brandon and Camillus...

What are you doing about ocean pollution?

  To many people watching Sky News and their #OceanFree Campaign, you would think that removing plastic from the oceans will be enough to resolve the problem. Sadly, this is not the case.   The oceans ability to provide food from fisheries and aquaculture is...

Daring to Dream Big

The definition of insanity is doing the same thing over and over again and expecting a different result - Albert Einstein   Another 300 million tonnes of plastic every year Since World War II we have consumed 5 billion tonnes of plastic, much of which has ended...

Have we Reached Peak Biofuel?

Is there really an energy security risk?   Former NATO Secretary General Anders Fogh Rasmussen is calling on Europe to increase the production of biofuels from an energy security perspective because of geopolitical risks. This is a tough ask if such increase in...

Biofuels Perfect Storm

Biofuels Perfect Storm   Since August 2015, ethanol has traded at a premium to gasoline which is unusual by historical standards. This is likely to continue until oil prices rebound into the $45-50 per barrel range. Even with this situation, 2015 ethanol...

Corny Problem for EU Sugar Producers

  The abolition of sugar quotas in 2017 will have such a profound effect on EU sugar producers, used to super profits under the EU supported Common Agricultural Policy (CAP), that many smaller producers will be subject to consolidation or have to cease...

Big Oil Can’t Alter Climate Change

  In a recent major MIT Study (Covert, Thomas, Michael Greenstone, and Christopher R. Knittel. 2016. "Will We Ever Stop Using Fossil Fuels?" Journal of Economic Perspectives, 30(1): 117-38. ) it was shown that approximately 65 percent of global greenhouse gas...

Butterfly Effect of Oil Price on Renewables

  The butterfly effect is a concept that small causes can have large effects. Initially, it was used with weather prediction but later the term became a metaphor used in and out of science. Now it can easily be related to a single decision made by a Saudi Oil...